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In addition, the inhibition of HDAC8 reverses the increased expression of -H2AX, an early marker of DNA double-strand breaks (DSB), and decreased expression of MRE11, a protein associated with DNA homologous recombination (HR) repair, thereby alleviating DNA damage and promoting its repair in kidney and renal epithelial cells (Wang et al., 2024c)

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Therapeutisches Forschungsprotokoll Dosierung: 5 10 mg (= 1020 Klicks) Dauer: 4 8 Wochen Hufigkeit: 3-5 Mal pro Woche Zyklusintervall: 4 Wochen Pause Ziel / Beschreibung: Fr fortgeschrittene Haut-, Wund- oder Haarforschung

doi: 10.1016/j.ccell.2014.11.019